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ES Journal of Clinical Trials

DOI: 10.59152/ESJCT/1002

Effects of Biophotonic Treatment on Hemoglobin A1c and Blood Oxygen Saturation

  • Brief Communication

  • Orien L Tulp1,3*, Syed A A Rizvi1,2, George P Einstein1,3
  • 1Professor, Colleges of Medicine and Graduate Studies, University of Science, Arts and Technology, Montserrat, British West Indies
  • 2Larkin Hospital, Miami FL, USA
  • 3The Einstein Medical Institute, N. Palm Beach, FL, USA
  • *Corresponding author: Orien L Tulp, Colleges of Medicine and Graduate Studies, University of Science, Arts and Technology, Montserrat, British West Indies and the Einstein Medical Institute, N. Palm Beach, FL, USA.
  • Received: December 08, 2023; Accepted: January 15, 2024; Published: January 31, 2024


Multiple biochemical events connected to UV irradiation from sunlight or other sources may induce either beneficial or damaging effects on tissue viability. The biophysiologic impact is dependent on the wavelengths encountered, the intensity and duration of the exposure, and the tissues exposed weather in vivo or in vitro as an extracorporeal exposure typical of that which is obtained following UV irradiation of freshly obtained heparinized whole blood. The applications of biophotonic therapy have been in use for nearly a century where its use has been found to be highly beneficial in the treatment of both infectious diseases of viral and microbial origin, in addition to enhancing immune responses, oxygenation of peripheral tissues and facilitating tissue regeneration and wound healing in a broad spectrum of disorders. In a short clinical trial, non-diabetic otherwise healthy subjects (n=8) were administered replicate biophotonic treatments during a single day, consisting of the timely reinfusion of 60 ml of heparinized, UV-exposed blood through a specialized quartz mixing cylinder during which the UV exposure occurred. The UV exposure occurred over a ~15-minute duration. Two hours after exposure, blood SpO2 remained increased by an average of 5% and hemoglobin A1c remained decreased by a similar proportion following completion of the biophotonic treatments. These results suggest that the biophotonic treatment contributed to an acute photodissociation of oxygen from oxyhemoglobin which may improve oxygen delivery to peripheral tissues, in concert with modest improvements in hemoglobin A1c as an indicator of glycemic control. Moreover, in related studies, the effects of biophotonic therapy on SpO2 have been reported to persist for at least one month following the treatment. Thus, the beneficial effects of UV-biophotonic treatment on HbA1c and SoO2 persist for at least 2 hours to 4 weeks following treatment, resulting in a broad spectrum of beneficial effects on health and vitality.


Diabetes, Hemoglobin A1c, Oxygen Saturation, Biophotonics.